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Endothelial Nox4 NADPH Oxidase …

Our results suggest that therapeutic strategies to modulate ROS production in vascular disease may need to separately target individual Nox isoforms. Skip to main content American Heart Association
http://atvb.ahajournals.org/content/31/6/1368

Endothelial NADPH oxidases: which NOX

NADPH oxidases (NOXs) are reactive oxygen species (ROS)-generating enzymes implicated in the pathophysiology of vascular diseases such as hypertension and stroke. Endothelial cells express four NOX isoforms including the superoxide-generating enzymes NOX1, NOX2, and NOX5 and the hydrogen peroxide-generating enzyme NOX4. …
https://www.readbyqxmd.com/read/25066192/endothelial-nadph...

Endothelial NADPH oxidases: which NOX

Endothelial NADPH oxidases: which NOX to target in vascular disease? Drummond G.R., Sobey C.G. NADPH oxidases (NOXs) are reactive oxygen species (ROS)-generating enzymes implicated in the pathophysiology of vascular diseases such as hypertension and stroke.
http://www.uniprot.org/citations/25066192

Endothelial NADPH oxidases: which NOX

Four NOX isoforms are expressed in the vascular wall, including NOX1 (in endothelial cells and vascular smooth-muscle cells, VSMCs), NOX2 (in endothelial cells, adventitial fibroblasts, and leukocytes such as monocytes, macrophages, and platelets), NOX4 (in endothelial cells, VSMCs, and adventitial fibroblasts), and NOX5 (in endothelial and …
https://www.sciencedirect.com/science/article/pii/S1043276014001234

Endothelial NADPH oxidases: which NOX

Endothelial NADPH oxidases: which NOX to target in vascular disease? Author: Grant R. Drummond,Christopher G. Sobey. Address: 1 Vascular Biology and Immunopharmacology Group, Department of Pharmacology, Monash University, Clayton, Victoria, Australia,2 Department of Surgery, Monash Medical Centre, Southern …
http://www.baikemy.com/periodical/view/subperiodical/13855757613313/61

Endothelial NADPH oxidases: Which

Except for Nox-5 and DUOX-1 and -2, Nox are phagocytic oxidases, whose main task is to generate ROS to kill foreign pathogens at homeostasis. Of note, the major source of endothelial cells ROS comes from NOX-1, -2, -4, and -5 ( Pendyala et al., 2009; Drummond and Sobey, 2014 Togliatto et al., 2017).
https://www.researchgate.net/publication/264242078_Endothelial...

Details and Download Full Text PDF: The …

NADPH (nicotinamide adenine dinucleotide phosphate) oxidases are important sources of reactive oxygen species (ROS). In the vascular system, ROS can have both beneficial and detrimental effects.
https://www.pubfacts.com/detail/22071588/The-Nox-family-of-NADPH...

Inducible nitric oxide synthase: Good or …

Nitric oxide synthases (NOS) are a family of isoforms responsible for the synthesis of the potent dilator nitric oxide (NO). Expression of inducible NOS (iNOS) occurs in conditions of inflammation, and produces large amounts of NO.
https://www.sciencedirect.com/science/article/pii/S0753332217313562

Endothelial NADPH oxidases: which NOX to target in ...

Endothelial NADPH oxidases: which NOX to target in vascular disease? Grant R. Drummond1,2 and Christopher G. Sobey1,2 1Vascular Biology and Immunopharmacology Group, Department of Pharmacology, Monash University, Clayton, Victoria,
http://www.cell.com/trends/endocrinology-metabolism/pdf/S1043-2760(14...

Opportunity Nox: The Future of NADPH …

Therefore, the redox-dependent effects of Nox signaling are contingent on Nox localization such that ROS are produced in a specific location to affect a specific target . These differences in modes of activation, subunit requirements, type of ROS produced, and Nox localization are means by which NADPH oxidases achieve specificity in cell signaling.
http://onlinelibrary.wiley.com/doi/10.1111/j.1755-5922.2011.00310.x/full