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Nox isoforms and chemokine receptors as …

Nox isoforms and chemokine receptors as therapeutic targets in vascular disease and stroke Drummond, Grant Raymond (Primary Chief Investigator (PCI)) Pharmacology
https://research.monash.edu/en/projects/nox-isoforms-and-chemokine...

Endothelial NADPH oxidases: Which NOX to target …

NADPH oxidases (NOXs) are reactive oxygen species (ROS)-generating enzymes implicated in the pathophysiology of vascular diseases such as hypertension and stroke.
https://www.researchgate.net/publication/264242078_Endothelial...

NAVER Academic > Endothelial NADPH oxidases: …

Endothelial NADPH oxidases: which NOX to target in vascular disease? Author Drummond Grant R, Sobey Christopher G Affiliation Vascular Biology and Immunopharmacology Group, Department of Pharmacology, Monash University, Clayton, Victoria, Australia, Vascular Biology and Immunopharmacology Group, Department of Pharmacology, Monash University ...
https://academic.naver.com/article.naver?doc_id=80690392

Endothelial NADPH oxidases: which NOX to target in ...

Endothelial NADPH oxidases: which NOX to target in vascular disease? Grant R. Drummond1,2 and Christopher G. Sobey1,2 1Vascular Biology and Immunopharmacology Group, Department of Pharmacology, Monash University, Clayton, Victoria,
https://www.cell.com/trends/endocrinology-metabolism/pdf/S1043...

Redox signaling, Nox5 and vascular remodeling in …

In hypertension, Nox-induced ROS production is increased, leading to perturbed redox signaling through oxidative modifications of vascular proteins. This influences mitogenic signaling and cell cycle regulation, leading to altered cell growth and vascular remodeling in hypertension.
http://www.ncbi.nlm.nih.gov › … › Lippincott Williams & Wilkins Open Access

Endothelial NADPH oxidases: which NOX to target in ...

The endothelium is a single layer of cells that lines the luminal surface of all blood vessels. In addition to its important role as the barrier between the circulating blood and underlying tissues, the endothelium is a key regulator of cardiovascular homeostasis and provides protection against vascular disease.
https://www.cell.com/trends/endocrinology-metabolism/fulltext/S...

Nox Inhibitors & Therapies: Rational Design of …

All Nox isoforms are characterized by a catalytic core, consisting of a bis-heme-containing transmembrane domain (6 – 7) and a C-terminal intracellular dehydrogenase tail that carries the required sites for FAD and NADPH binding. p22 phox, a membrane-bound component present in Nox1-, Nox2, Nox3 and Nox4 complexes (but not in those of Nox5, Duox1 or Duox2), stabilizes its Nox counterpart …
http://www.ncbi.nlm.nih.gov › Journal List › HHS Author Manuscripts

Erythrocytes From Patients With Type 2 Diabetes …

This involves an RBC-derived H 2 O 2-induced increase in vascular arginase I and vascular H 2 O 2 formation derived from vascular NOX1, which ultimately induce endothelial dysfunction. Our findings suggest that RBCs, specifically RBC arginase I, are potential therapeutic targets for the treatment of endothelial dysfunction in patients with T2DM.
https://www.sciencedirect.com/science/article/pii/S073510971835188X

Endothelial NADPH oxidases: which NOX to target in ...

Four NOX isoforms are expressed in the vascular wall, including NOX1 (in endothelial cells and vascular smooth-muscle cells, VSMCs), NOX2 (in endothelial cells, adventitial fibroblasts, and leukocytes such as monocytes, macrophages, and platelets), NOX4 (in endothelial cells, VSMCs, and adventitial fibroblasts), and NOX5 (in endothelial and VSMCs – not expressed in rodents).
https://www.sciencedirect.com/science/article/pii/S1043276014001234

Special Issue "ROS Derived from NADPH Oxidase …

Angiogenesis is the formation of new blood vessels from preexisting ones and is implicated in physiologic vascular development, pathologic blood vessel growth, and vascular restoration. This is in contrast to vasculogenesis, which is de novo growth of vessels from vascular precursors, or from
https://www.mdpi.com/journal/antioxidants/special_issues/ros...